1-bromo-3-tert-butyl-5-chlorobenzene

Specification: Enterprise standard
CAS: 1263377-20-3

 

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Basic Information

Product Name: 1-Bromo-3-tert-butyl-5-chlorobenzene

Chinese Name: 1-溴-3-叔丁基-5-氯苯

Molecular Formula: C₁₀H₁₂BrCl

Molecular Weight: 247.56 g/mol

Structure: This compound is a benzene ring substituted with a bromine atom at the 1-position, a tert-butyl group at the 3-position, and a chlorine atom at the 5-position.


1-Bromo-3-tert-butyl-5-chlorobenzene is a halogenated aromatic compound used as an intermediate in organic synthesis. The presence of bromine and chlorine atoms allows for versatile reactivity, especially in cross-coupling reactions, while the bulky tert-butyl group influences steric and electronic properties. This makes it valuable in pharmaceutical and materials chemistry.

 

Main Uses

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.

Building block for advanced aromatic compounds through coupling reactions.

Used in material science for designing functional aromatic structures.

 

Typical Applications

Participation in Suzuki, Stille, and Heck cross-coupling reactions.

Formation of Grignard reagents at the bromine site for further transformations.

 

Synthesis of sterically hindered aromatic derivatives with tailored properties.