2-Bromoindene

Basic Information

Product name: 2-Bromoindene

Chinese name: 2-溴茚

Molecular Formula: C₉H₇Br

Molecular weight: 195.06 g/mol

Structure: This is an indene derivative with a bromine atom substituted at the 2-position of the fused bicyclic aromatic system consisting of a benzene ring fused to a cyclopentene ring.

2-Bromoindene is a brominated bicyclic aromatic hydrocarbon that serves as a useful intermediate in organic synthesis. The bromine substituent at the 2-position allows for further functionalization through cross-coupling and other substitution reactions, making it valuable in the preparation of pharmaceuticals, agrochemicals, and organic materials.

Main Uses

Organic Synthesis Intermediate

• Utilized in the synthesis of more complex indene derivatives and heterocyclic compounds through cross-coupling reactions such as Suzuki, Stille, and Heck.

Pharmaceutical Research

• Acts as a building block in the development of bioactive molecules featuring the indene scaffold.

Material Science

• Used in the preparation of specialty polymers and organic electronic materials involving indene-based structures.

Typical Applications

Suzuki Coupling

Reacts with boronic acids or esters to form new C-C bonds, enabling the synthesis of diverse substituted indenes.

Grignard Reagent Formation

The bromine can be converted to a Grignard reagent for further carbon–carbon bond-forming reactions.

Electrophilic Substitution

Provides a site for electrophilic aromatic substitution due to the activated bromine substituent.